Thyroid: Anaplastic (undifferentiated) carcinoma

Undifferentiated thyroid carcinoma.

Undifferentiated carcinoma (also known as anaplastic carcinoma) of the thyroid gland is a highly aggressive malignant neoplasm composed of undifferentiated cells that exhibit immunohistochemical or ultrastructural epithelial differentiation. Nearly all patients report a long history of thyroid gland disease, often goiter or Hashimoto thyroiditis. In most cases, there is a transformation from a ...

Anaplastic thyroid carcinoma

Anaplastic Thyroid Carcinoma

Thyroid cancers represent about 1% of all human cancers. Differentiate thyroid carcinomas (DTCs), papillary and follicular cancers, are the most frequent forms, instead Anaplastic Thyroid Carcinoma (ATC) is estimated to comprise 1-2% of thyroid malignancies and it accounts for 14-39% of thyroid cancer deaths. The annual incidence of ATC is about one to two cases/million, with the overall incide...

Plitidepsin has a cytostatic effect in human undifferentiated (anaplastic) thyroid carcinoma.

Undifferentiated (anaplastic) thyroid carcinoma is a highly aggressive human cancer with very poor prognosis. Although there have been a few studies of candidate treatments, the fact that it is an infrequent tumor makes it very difficult to design clinical trials. A strong association has been observed between undifferentiated thyroid carcinoma and TP53 mutations in numerous molecular genetic a...

Undifferentiated Thyroid Carcinoma Caused Sudden Airway Obstruction

Case report An 81-year-old woman was admitted to our emergency department (ED) with neck swelling (Figure 1A) and advancing dyspnea. Stridor was noted on auscultation of her neck, and her breathing was labored. We immediately diagnosed airway obstruction, and emergency intubation was performed using a video laryngoscope (AWS-S100L®, Pentax Corporation, Tokyo, Japan). The epiglottis was found to...